Acute graft versus host disease (aGVHD) is a leading cause of mortality after allogeneic hematopoietic cell transplantation (alloHCT), regardless of HLA compatibility between donor and recipient pairs. Here, we conducted a systematic data-driven mining on 1,366 samples for genetic risks contributed to aGVHD after HLA-haploidentical HCT (haploHCT). Through whole genome sequencing on 212 donor-recipient pairs followed by target sequencing on the extended 471 pairs, we systematically discovered and confirmed aGVHD-associated genetic variants in pairwise donors and recipients genome-widely. Here, we provided the detailed information of aGVHD-related SNPs, LoF genes, SVs and CNVs in this database.



Search the SNP, gene and genomic region for aGVHD-associated variations:


Examples: rs2069762, EFCAB5, chr9:33708000-33708500


Search the LOF gene pairs in the aGVHD database: